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Acute myelogenous leukemia (AML)
Definition
Disease: | Acute myelogenous leukemia (AML) | ![]() |
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Category: | Blood diseases & tumors |
Disease Definition:
Also known as acute myeloblastic leukemia, acute nonlymphocytic leukemia, acute myeloblastic leukemia and acute myeloid leukemia, AML (acute myelogenous leukemia) is a type of cancer of the blood and bone marrow, which is the spongy tissue inside bones where blood cells are made. In acute myelogenous leukemia, the word "acute" refers to the fact that the disease affects immature blood cells and progresses rapidly. Myelogenous refers to the white blood cells, which are called myeloid cells that AML affects.
The myeloid cells develop into the various types of mature blood cells, such as white blood cells, red blood cells and platelets.
Work Group:
Prepared by: Scientific Section
Symptoms, Causes
Symptoms: Many signs and symptoms of the early stages of AML can resemble those of the flu or other common diseases. These signs may also vary according to the type of the blood cell affected. AML signs and symptoms may include:
AML worsens quickly if not treated, so a prompt diagnosis is helpful. In case unusually or worrisome signs and symptoms are noticed, a doctor should be consulted. |
Causes:
AML occurs when the DNA of developing cells in the bone marrow is damaged, causing blood cell production to become uneven. Although the cause of DNA mutations that lead to leukemia are not clear, radiation, exposure to certain chemicals and some chemotherapy drugs may play a role. It is also believed that most cases of acute myelogenous leukemia aren't inherited. |
Complications
Complications: None |
Treatments: AML treatment depends on several factors, such as the patient’s age, overall health, preferences and the subtype of the disease. The treatment of this disease has two phases:
THE 1ST PHASE: INDUCTION THERAPY
THE 2ND PHASE: CONSOLIDATION THERAPY Some of the therapy methods that are used in these phases are:
Biological therapy:
Chemotherapy:
Bone marrow stem cell transplant:
Other drug therapy: |
Prognosis: Not available |
Dr. Faisal Dibsi
Dr. Talal Sabouni
Samir Moussa M.D.
Yaser Habrawi , F.R.C.S.Ed
Dr. Hani Najjar
Dr. Tahsin Martini
Dr . Dirar Abboud
Dr. Samer Al-Jneidy