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Malignant Lymphoma of the Lacrimal Gland: A Nation-Based Study



Malignant Lymphoma of the Lacrimal Gland: A Nation-Based Study

Peter Rasmussen, MD; Elisabeth Ralfkiaer, MD, DMSc; Jan Ulrik Prause, MD, DMSc; Lene D. Sjö, MD, PhD; Volkert D. Siersma, MSc, PhD; Steffen Heegaard, MD, DMSc

Archives of Ophthalmology,
129:10, October 10, 2011

Malignant Lymphoma of the Lacrimal Gland: A Nation-Based Study

Objective 
To characterize the clinicopathologic features of lacrimal gland lymphoma.


Methods 
All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected.


Results 
Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43-87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large B-cell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lymphoma, 1 patient (4%) had stage III lymphoma, and 4 patients (15%) had stage IV lymphoma. Patients with stage I or II lymphoma were treated with radiotherapy (15 [67%]), chemotherapy (3 [14%]), chemotherapy plus radiotherapy (1 [5%]), and surgery (3 [14%]). Patients presenting with stage III or IV lymphoma were treated with chemotherapy alone. Complete remission was observed in 23 of the patients (85%), although 12 (44%) of these had a relapse, independent of subtype, stage, or treatment. The 5-year overall survival was 70%.


Conclusions 
Malignant lymphoma of the lacrimal gland is relatively rare and is mostly prevalent in elderly women. The distribution of lacrimal gland lymphoma subtypes resembles that of lymphoma subtypes of the salivary glands. The majority of lacrimal gland lymphomas are low grade, and the prognosis is relatively good.







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Prepared by: Dr. Houssam Al-Nahhas






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