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Indications:

Morphine, a controlled-release tablet containing morphine, is used to relieve moderate to severe pain. While regular morphine is usually given every 4 hours, Morphine is typically taken every 12 hours—only twice a day. The Kadian brand may be taken once or twice a day. The drugs are intended for people who need a morphine painkiller for more than just a few days.

Contraindications:

Do not take Morphine if you have ever had an allergic reaction to morphine or are sensitive to it, or if you have bronchial asthma. If your breathing is abnormally slow, you should not take Morphine unless there is resuscitation equipment nearby. Morphine should not be prescribed if you are suffering an intestinal blockage.

Adverse reactions:

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor immediately. Only your doctor can determine whether it is safe for you to continue taking Morphine . As with other narcotics, the most hazardous potential side effect of Morphine is respiratory depression (dangerously slow breathing). If you are older or in a weakened condition, you are particularly vulnerable to respiratory depression; you may be at special risk at any age if you have a lung or breathing problem. Side effects may include: Anxiety, constipation, depressed or irritable mood, dizziness, drowsiness, exaggerated sense of well-being, light-headedness, nausea, sedation, sweating, vomiting You may be able to lessen some of these side effects by lying down. If you stop taking Morphine after a long period of use, you will probably experience some degree of narcotic withdrawal syndrome. During the first 24 hours, you may have: dilated pupils, goose bumps, restlessness, restless sleep, runny nose, sweating, tearing, or yawning. Over the next 72 hours, the following may be added: Abdominal and leg pains, abdominal and muscle cramps, anxiety, diarrhea, hot and cold flashes, inability to fall or stay asleep, increase in body temperature, blood pressure, and breathing and heart rate, kicking movements, loss of appetite, nasal discharge, nausea, severe backache, sneezing, twitching and spasm of muscles, vomiting, weakness Even without treatment, your withdrawal symptoms will probably disappear within a week or two. However, you could experience a second phase of withdrawal, involving aching muscles, irritability, and insomnia, which might last for 2 to 6 months.

Interactions:

If MS Contin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining MS Contin with the following: Alcohol Certain analgesics such as buprenorphine, butorphanol, nalbuphine, and pentazocine Drugs that control vomiting, such as prochlorperazine and trimethobenzamide Drugs classified as MAO inhibitors, such as the antidepressants phenelzine and tranylcypromine Major tranquilizers such as chlorpromazine and haloperidol Muscle relaxants such as cyclobenzaprine and diazepam Sedatives such as flurazepam and triazolam Tranquilizers such as alprazolam and chlordiazepoxide Water pills such as chlorothiazide and furosemide

Warnings:

Like other narcotics, Morphine is potentially addictive. If you take Morphine for some time and then stop abruptly, you could experience withdrawal symptoms. For this reason, do not make dosage changes on your own; always consult your doctor. Morphine should not be used by anyone who might have a brain injury, or the beginnings of an abdominal problem requiring surgery; the drug could mask the symptoms, making correct diagnosis difficult or impossible. For people facing biliary tract surgery, there is a chance that the drug could make their condition worse. Your doctor will also prescribe Morphine with extreme caution if you have any of the following conditions: Alcoholism Coma Curvature of the spine Delirium tremens (severe alcohol withdrawal) Drug-related psychosis Enlarged prostate or constricted urinary canal Kidney disorder Liver disorder Low adrenalin levels Low thyroid levels Lung disorder Swallowing difficulty If taken by an epileptic person, Morphine could increase the likelihood of a seizure. Since Morphine can impair judgment and coordination, do not drive, climb, or operate hazardous equipment while taking Morphine sulfate. If you become overly calm or lethargic, call your doctor. Morphine can lower blood pressure; you may feel dizzy or light-headed, especially when you first stand up. If you are pregnant or plan to become pregnant, inform your doctor immediately. Although there is no evidence so far that a pregnant woman’s short-term use of Morphine can harm her unborn baby, Morphine sulfate should be taken during pregnancy only if the benefit to the mother outweighs a possible risk to the child. Morphine is not recommended for use as a painkiller during childbirth. If a woman takes Morphine sulfate shortly before giving birth, her baby may have trouble breathing. Babies born to mothers who use morphine chronically may suffer from drug withdrawal symptoms. Since some of the morphine from Morphine appears in breast milk, do not take Morphine sulfate while breastfeeding. If you do nurse while using Morphine , your baby could experience withdrawal symptoms once you stop taking Morphine sulfate.

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