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Mycobutin

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Indications:

Prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

Contraindications:

Hypersensitivity to rifabutin or other rifamycins; active tuberculosis

Adverse reactions:

Cardiovascular Chest pain. CNS Asthenia; headache; insomnia. Dermatologic Rash. EENT Taste perversion. GI Anorexia; diarrhea; dyspepsia; abdominal pain; eructation; flatulence; nausea; vomiting. Genitourinary Discolored urine. Hematologic Anemia; eosinophilia; leukopenia; neutropenia; thrombocytopenia. Metabolic Increased alkaline phosphatase, AST, and ALT. Miscellaneous Myalgia; fever; discolored saliva, sputum, tears, or skin.

Interactions:

Azole antifungal agents, benzodiazepines, beta blockers, buspirone, chloramphenicol, clarithromycin, clozapine, oral contraceptives, corticosteroids, cyclosporine, delavirdine, digitoxin, disopyramide, doxycycline, erythromycin, estrogens, haloperidol, hydantoins, indinavir, losartan, methadone, mexiletine, morphine, nelfinavir, ondansetron, oral anticoagulants, quinidine, quinine, ritonavir, sulfonylureas, tacrolimus, tamoxifen, theophyllines, tocainide, toremifene, tricyclic antidepressants, troleandomycin, verapamil, zolpidem Therapeutic efficacy may be decreased because of liver enzyme-inducing properties of rifabutin. Indinavir, itraconazole, ritonavir May elevate rifabutin plasma levels, increasing the risk of side effects. Ketoconazole May reduce rifabutin plasma levels, decreasing the therapeutic effects. Zidovudine May decrease plasma levels of zidovudine.

Warnings:

Pregnancy Category B Lactation Unknown. Discontinue nursing or discontinue drug. Children Safety and efficacy not established. Based on the limited data available, there is no evidence that doses higher than 5 mg/kg daily are useful.

Form:

CAPSULE

Dosage and Administration

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