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1-alpha

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Indications:

This medicine is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function. The main indications are: a) Renal osteodystrophy b) Hyperparathyroidism (with bone disease) c) Hypoparathyroidism d) Neonatal hypocalcaemia e) Nutritional and malabsorptive rickets and osteomalacia f) Pseudo-deficiency (D-dependent) rickets and osteomalacia g) Hypophosphataemic vitamin D resistant rickets and osteomalacia

Contraindications:

Hypercalcaemia, metastatic calcification. Hypersensitivity to alfacalcidol or any of the other ingredients

Adverse reactions:

• Metabolism and Nutrition Disorders Hypercalcaemia Hyperphosphataemia • Skin and Subcutaneous Tissue Disorders Pruritus Rash Urticaria • Renal and Urinary Disorders Nephrocalcinosis Renal impairment

Interactions:

Patients taking barbiturates or anticonvulsants may require larger doses of this medicine to produce the desired effect due to the induction of hepatic detoxification enzymes. Concomitant administration of colestyramine may interfere with the intestinal absorption of alfacalcidol. Use with caution in patients being treated with thiazide diuretics as they may have an increased risk of developing hypercalcaemia.

Warnings:

This medicine should be used with caution for: • patients being treated with cardioactive glycosides or digitalis as hypercalcaemia may lead to arrhythmia in such patients • patients with nephrolithiasis

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