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Treatment of infections of urinary tract, lower respiratory tract, skin and skin structures, bone and joint; treatment of gynecological infections; treatment of intra-abdominal infections caused by susceptible strains of specific microorganisms; perioperative prophylaxis. Concomitant antibiotic therapy If cefotetan and an aminoglycoside are to be used concomitantly, carefully monitor renal function, especially if higher dosages of the aminoglycoside are to be administered or if therapy is to be prolonged, because of the potential nephrotoxicity and ototoxicity of aminoglycosides


Hypersensitivity to cephalosporins.

Adverse reactions:

GI Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis. Genitourinary Pyuria; renal dysfunction; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy. Hematologic Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. Hepatic Hepatic dysfunction; abnormal LFT results. Miscellaneous Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness–like reactions (eg, skin rashes, polyarthritis; arthralgia, fever); phlebitis, thrombophlebitis, and pain at injection site.


Alcohol Acute alcohol intolerance (disulfiram-like reaction) may occur up to 3 days after last dose of cefotetan. Aminoglycosides Increased risk of nephrotoxicity. Anticoagulants, oral Increased anticoagulant effect; bleeding complications may occur. Incompatibility Aminoglycosides Do not add aminoglycosides to cefotetan solutions because inactivation of both drugs may result; administer at separate sites if concurrent therapy is indicated. Laboratory Test Interactions May cause false-positive urine glucose test results with Benedict’s solution, Fehling’s solution, or Clinitest tablets but not with enzyme-based tests (eg, Clinistix , Tes-tape ); false-positive test result for proteinuria with acid and denaturization-precipitation tests; false-positive direct Coombs ’ test results in certain patients (eg, those with azotemia); false elevations in urinary 17-ketosteroid values. High concentrations may interfere with creatinine concentrations measured by the Jaffe reaction, producing false results; do not analyze serum samples for creatinine if obtained within 2 hr of drug administration.


Monitor Coagulation abnormalities Monitor for coagulation abnormalities. Elevate prothrombin time or abnormal platelet count may occur. If bleeding occurs and PT is prolonged, vitamin K may be indicated. Response to therapy Monitor patient’s response to therapy. Notify health care provider if infection does not appear to improve or worsens. Side effects Monitor patient for GI, DERM, and general body side effects, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping. Pregnancy Category B . Lactation Excreted in breast milk. Children Safety and efficacy in children not established. Hypersensitivity Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible cross-reactivity. Renal Function Use drug with caution in patients with renal impairment. Dosage adjustment based on renal function may be required. Superinfection May result in bacterial or fungal overgrowth of nonsusceptible microorganisms. Pseudomembranous colitis Consider in patients who develop diarrhea.



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