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Suspension Cefrax®

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Indications:

Treatment of infections of lower respiratory tract, skin and skin structures, urinary tract, bone and joint; treatment of gynecological infections; treatment of intra-abdominal infections; treatment of septicemia and CNS infections including meningitis caused by susceptible strains of specific microorganisms; concomitant antibiotic therapy.

Contraindications:

Hypersensitivity to cephalosporins

Adverse reactions:

GI Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis. Genitourinary Pyuria; renal dysfunction; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy. Hematologic Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; thrombocytosis; decreased platelet function; anemia; aplastic anemia; hemorrhage. Hepatic Hepatic function impairment; cholestatic jaundice; abnormal LFT results. Miscellaneous Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness–like reactions (eg, skin rashes, polyarthritis, arthralgia, fever); phlebitis; thrombophlebitis, and pain at injection site.

Interactions:

Aminoglycosides Increased risk of nephrotoxicity. Incompatibility Aminoglycosides Do not add aminoglycosides to ceftazidime solutions because inactivation of both drugs may result; administer at separate sites if concurrent therapy is indicated. Sodium bicarbonate Do not dilute ceftazidime with sodium bicarbonate. Laboratory Test Interactions May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets but not with enzyme-based tests (eg, Clinistix , Tes-Tape ); false-positive test results for proteinuria with acid and denaturization-precipitation tests; false-positive direct Coombs test result in certain patients (eg, those with azotemia); false elevations in urinary 17-ketosteroid values

Warnings:

Monitor Response to therapy Monitor patient’s response to therapy. Notify health care provider if infection does not appear to improve or worsens. Adverse reactions Monitor patient for GI, DERM, and general body adverse reactions, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping. Pregnancy Category B . Lactation Excreted in breast milk. Hypersensitivity Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible cross-reactivity. Renal Function Use drug with caution in patients with renal function impairment. Dosage adjustment based on renal function may be required. Superinfection May result in bacterial or fungal overgrowth of nonsusceptible microorganisms. Pseudomembranous colitis Consider in patients in whom diarrhea develops.

Form:

SUSPENSION

Dosage and Administration

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Consultants Corner

Dr. Tahsin Martini

Dr. Tahsin Martini Degree status: M.D. in Ophthalmology

Dr. Samer Al-Jneidy

Dr. Samer Al-Jneidy Pediatrician

Dr. Faisal Dibsi

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Dr . Dirar Abboud

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Dr. Talal Sabouni

Dr. Talal Sabouni UROLOGY AND KIDNEY TRANSPLANT

Samir Moussa M.D.

Samir Moussa M.D. ENT Specialist

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist
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