Indications:

As an adjunct in the treatment of all forms of Parkinson. It is also used in the control of drug-induced extra pyramidal disorders

Contraindications:

Dose-dependent side effects are frequent. Particularly geriatric patients may react with confusional states or develop delirium. * CNS : Drowsiness, vertigo, headache, and dizziness are frequent. With high doses nervousness, agitation, anxiety, delirium, and confusion are noted. Trihexyphenidyl may be abused due to a short acting mood-elevating and euphoriant effect. The normal sleep architecture may be altered (REM sleep depression). Trihexyphenidyl may lower the seizure-threshold. * Peripheral side effects : Blurred vision, dry mouth, impaired sweating, abdominal discomfort, and obstipation are frequent. Tachycardia may be noted. Allergic skin reactions may occur. Parenteral use may cause orthostatic hypotension. * Eyes : Trihexyphenidyl causes mydriasis with or without photophobia. It may precipitate narrow angle glaucoma. * Tolerance may develop during therapy which requires dose adjustments.

Adverse reactions:

# Hypersensitivity to trihexyphenidyl # Narrow angle glaucoma # Ileus

Interactions:

Cannabinoids, barbiturates, opiates, and alcohol may have additive effects with ARTANE, and thus, an abuse potential exists. Concurrent use of alcohol or other CNS depressants with ARTANE may cause increased sedative effects. Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications. Prophylactic administration of anticholinergic agents, such as trihexyphenidyl, as a prevention of drug-induced parkinsonism during neuroleptic therapy is not recommended. There may be an increased risk for the development of tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics (see PRECAUTIONS, General). The usual dose of either trihexyphenidyl or levodopa may need to be reduced during concomitant therapy, since concomitant administration may increase drug-induced involuntary movements

Warnings:

Some medical conditions may interact with Trihexyphenidyl. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have high blood pressure, liver or kidney problems, heart problems (eg, irregular heartbeat), blood vessel problems (eg, narrowing), prostate problems, or difficulty urinating if you have a history of involuntary movements of the face, tongue, lips, trunk, or extremities if you have open-angle glaucoma or you are at risk for glaucoma

Form:

SOLUTION FOR INJECTION