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Clozan

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Indications:

Sleep disorders-anxiety

Contraindications:

Acute narrow-angle glaucoma; myasthenia gravis; respiratory depression; coma; acute pulmonary insufficiency; sleep apnoea syndrome; severe hepatic impairment. Chronic psychosis. Porphyria. Should not be used alone to treat depression or anxiety associated with depression.

Adverse reactions:

Hepatotoxicity. Drowsiness and lightheadedness, sedation, muscle weakness, and ataxia. Less frequently, vertigo, headache, confusion, depression, slurred speech or dysarthria, changes in libido, tremor, visual disturbances, urinary retention or incontinence, GI disturbances, changes in salivation, and amnesia.

Interactions:

MAOIs. Enhanced sedation or respiratory and CV depression may occur if given with other drugs that have CNS depressant properties. Others: Fenoprofen, methadone, pethidine and opioid analgesics; disopyramide, lidocaine and quinidine; chloramphenicol, doxycycline; warfarin and coumarin; antidepressants eg, bupropion, fluoxetine, lithium and mianserin; valproate and progabide; vigabatrin, oxcarbazepine, carbamazepine, clonazepam, ethosuximide, lamotrigine, tiagabine and zonisamide, griseofulvin; teniposide; metronidazole; chlorpromazine; HIV-protease inhibitors; β-blockers; calcium-channel blockers e.g. nifedipine and verapamil; digitoxin; ciclosporin; corticosteroids; furosemide; montelukast; oral contraceptives; theophylline; levothyroxine; influenza vaccination and vitamins. Alcohol.

Warnings:

Chronic pulmonary insufficiency, muscle weakness, organic brain changes, impaired liver or kidney function, or in patients with history of alcohol or drug addiction. May affect performance of skilled tasks. May precipitate suicide or aggressive behaviour. Personality disorders. Hypotension occasionally occur with high dosage and parenteral admin. Elderly or debilitated patients. Pregnancy and lactation.

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