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Xanthium

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Indications:

Acute or chronic bronchospasm.

Contraindications:

Hypersensitivity to xanthine derivatives, porphyria.

Adverse reactions:

Nausea, vomiting, abdominal pain, diarrhoea, headache, insomnia, dizziness, anxiety, restlessness, tremor, palpitations. Potentially Fatal: Convulsions, cardiac arrhythmias, hypotension and sudden death after too rapid IV inj.

Interactions:

Other xanthines. Theophylline clearance reduced by high dose allopurinol, some antiarrhythmics, cimetidine, disulfiram, propranolol, methotrexate, aciclovir, mexiletine, pentoxifylline, tacrine, ticlopidine, fluvoxamine, interferon-?, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Theophylline clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, aminoglutethimide, barbiturates, ipriflavone, cigarette smoking. Concurrent use decreased lithium, alprazolam levels. Increased risk of arrhythmias with ephedrine, sympathomimetic, general anaesthetics. Increased heart rate with tadalafil.

Warnings:

Admin IV inj very slowly to avoid direct stimulation of the CNS and CVS. Cardiac failure, hypertension, epilepsy, hyperthyroidism, history of peptic ulcer disease, renal or hepatic dysfunction, glaucoma, DM, severe hypoxaemia, chronic alcoholism, acute febrile illness. On influenza immunization or active influenza infection, COPD and cor pulmonale. Smokers may need higher dose. Pregnancy, lactation, children and elderly.

Form:

SOLUTION FOR INJECTION

Dosage and Administration

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