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Prostin E2

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Indications:

Cervical priming, induction and augmentation of labour. Labour induction. Pregnancy termination in the 2nd trimester.

Contraindications:

Hypersensitivity to prostaglandins. Patients in whom oxytocics are generally contraindicated. History of pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.

Adverse reactions:

Hypersensitivity reactions, nausea, vomiting, diarrhoea, abdominal pain; flushing, shivering, headache, dizziness; hypertension; convulsions, ECG changes,local tissue irritation, erythema; pyrexia, increased WBC. Uterine contractile abnormalities with or without foetal distress. Dosage >0.5 mg intracervically can cause hypertonic uterine contractions. Intra/extra-amniotic inj: Local infection, vomiting, diarrhoea, pyrexia, transient hypotension. Potentially Fatal: Sudden CV collapse due to accidental IV absorption and intra-amniotic inj. Uterine rupture, amniotic fluid embolism during labour. Foetal distress and death in rare cases.

Interactions:

Warnings:

Raised intraocular pressure. Previous caesarean section; history of asthma, epilepsy, hepatic or renal dysfunction cardiovascular disease; pregnancy. Pregnancy: Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

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SOLUTION FOR INJECTION

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