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Dothep

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Indications:

Depression

Contraindications:

Hypersensitivity, recent MI, neonates, heart block, cardiac arrhythmias, mania, alcohol, other CNS depressants, severe liver disease, prostate disease, children.

Adverse reactions:

Cholestatic jaundice, sexual dysfunction, exacerbation of psychotic manifestation, cardiac arrhythmias, hypotension, dry mouth, constipation, disturbance of accommodation, tachycardia, postural hypotension, drowsiness, tremors and skin rash. Withdrawal symptoms with abrupt cessation: Insomnia, irritability and excessive sweating. Potentially Fatal: Bone marrow depression, cardiac arrhythmias and agranulocytosis, reports of ventricular fibrillation and renal failure.

Interactions:

Barbiturates reduce antidepressant effect of dosulepin. Raised serum concentrations with methylphenidate. Cigarette smoking enhances metabolism. Increased risk of ventricular arrhythmias when used with drugs that prolong QT interval. Potentially Fatal: Should not be given concurrently or within 14 days of stopping MAOIs. Potentiates catecholamines sympathomimetics, narcotics and alcohol. Reduces hypotensive activity of bethanidine, guanethidine.

Warnings:

Epilepsy, hypertension, glaucoma, urinary retention, gradual withdrawal, pregnancy, lactation, elderly. Pregnancy: Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Form:

SOLUTION FOR INJECTION

Dosage and Administration

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Consultants Corner

Dr . Dirar Abboud

Dr . Dirar Abboud Hepatologist – Gastroenterologist

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

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Dr. Tahsin Martini Degree status: M.D. in Ophthalmology

Dr. Faisal Dibsi

Dr. Faisal Dibsi Specialist of Otolaryngology - Head and Neck Surgery

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Dr. Samer Al-Jneidy Pediatrician
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