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Indications:

This medicine is indicated for the treatment of erectile dysfunction.

Contraindications:

This medicine is contraindicated in men with any of the following: - Known hypersensitivity to alprostadil. - Abnormal penile anatomy: This medicine is contraindicated in patients with urethral stricture, balanitis (inflammation/infection of the glans of the penis), severe hypospadias and curvature, and in patients with acute or chronic urethritis. - Sickle cell anemia or trait, thrombocythemia, polycythemia, multiple myeloma: This medicine is contraindicated in patients who are prone to venous thrombosis or who have a hyperviscosity syndrome and are therefore at increased risk of priapism (rigid erection lasting 6 or more hours). - This medicine should not be used in men for whom sexual activity is inadvisable. - This medicine should not be used for sexual intercourse with a pregnant woman unless the couple uses a condom barrier.

Adverse reactions:

Penile Pain, Urethral Burning, Minor Urethral Bleeding/Spotting Testicular Pain

Interactions:

The concomitant use of this medicine and anti-hypertensive medications may increase the risk of hypotension.

Warnings:

• A complete medical history and physical examination should be undertaken to exclude reversible causes of erectile dysfunction prior to the initiation of the therapy. In addition, underlying disorders that might preclude the use of this medicine should be sought. • Cardiovascular effects: During in-clinic dosing, patients should be monitored for symptoms of hypotension, and the lowest effective dose of this medicine should be prescribed. • Hematologic effects: Patients administering this medicine improperly may be at risk of urethral abrasion resulting in minor bleeding or spotting. Patients on anticoagulant therapy or with bleeding disorders may be at higher risk of bleeding. Patients on anticoagulant therapy have been safely treated with this medicine; however, the risk/benefit ratio in these patients should be considered prior to prescribing this medicine. • Resumption of sexual activity: Sexual intercourse is considered a vigorous physical activity, and it increases heart rate as well as cardiac work. Physicians may want to examine the cardiac fitness of patients prior to treating erectile dysfunction. • Priapism and prolonged erection: In clinical trials of this medicine, priapism (rigid erection lasting ≥6 hours) and prolonged erection (rigid erection lasting 4 hours and <6 hours) were reported infrequently (<0.1% and 0.3% of patients, respectively). Nevertheless, these events are a potential risk of pharmacologic therapy and can cause penile injury. Physicians should lower the dose or consider discontinuing the treatment in any patient who develops priapism or prolonged erection.

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