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Aldactazine

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Indications:

* Hypertension. * Edema of renal, cardiac and liver.

Contraindications:

This medicine SHOULD NOT BE USED if: . hypersensitivity to sulfonamides; . Hypersensitivity to spironolactone; . Severe acute renal failure or particular: anuria, renal dysfunction rapidly evolving; . hyperkalemia; . end-stage liver failure; . association with other diuretics, potassium salts (except in cases of hypokalemia) . Due to the presence of lactose, the drug-cons is indicated for congenital galactosemia, malabsorption of glucose and galactose or lactase deficiency.

Adverse reactions:

RELATED Spironolactone: - These side effects have been observed in adults: Gynecomastia may occur during the use of spironolactone: its development seems to be in relationship with both the dosage used with the duration of therapy and is usually reversible on stopping the administration of spironolactone; However, in rare cases it can persist. - Other side effects rare and usually reversible upon discontinuation of the drug were encountered, they are: . impotence in man . menstrual disorders in women . gastrointestinal intolerance, . rash . drowsiness . leg cramps. - At the biological Under spironolactone, serum potassium may increase moderately. The most significant are reported hyperkalemia in renal failure and in patients on ACE inhibitors or potassium supplements: although the vast majority of these are asymptomatic hyperkalemia, shall be promptly corrected. If hyperkalemia, treatment with spironolactone is stopped. These disorders are usually reversible upon discontinuation of treatment. RELATED ALTIZIDE: The biological or clinical side effects are usually dose-dependent and can be reduced by finding the lowest effective dose, especially in hypertension. Thiazides and related can cause: - At the biological . potassium depletion with hypokalaemia particularly where intensive diuresis, and particularly acute in certain populations at risk (see precautions). . hyponatremia with hypovolemia to cause dehydration and orthostatic hypotension. The concomitant loss of chloride ions can cause a secondary compensatory metabolic alkalosis: the incidence and magnitude of this effect is weak. . Elevation of serum uric acid and blood glucose during treatment: the use of these diuretics is discussed thoroughly in patients with diabetes and gout. . hematological disorders, much more rare, thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, hemolytic anemia. . hypercalcemia exceptional. - In clinical terms: . in cases of liver failure, possibility of occurrence of hepatic encephalopathy (see cons-indications and warnings) . Hypersensitivity reactions, mainly dermatological, in subjects prone to allergic reactions and asthma, . cases of photosensitivity reaction (uncommon) have been reported (see section Warnings and precautions for use) . maculopapular rash, purpura, possible aggravation of a preexisting lupus erythematosus, . nausea, constipation, dizziness, asthenia, paresthesia, headache, rarely seen and often yielding a reduction of dosage, . exceptionally: pancreatitis.

Interactions:

Warnings:

Form:

SOLUTION FOR INJECTION

Dosage and Administration

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Consultants Corner

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

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