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Indications:

Management of hypertension and symptomatic benign prostatic hyperplasia (BPH).

Contraindications:

Hypersensitivity to doxazosin or prazosin.

Adverse reactions:

Cardiovascular Palpitations; orthostatic hypotension; hypotension; tachycardia; arrhythmias; vasodilation. CNS Dizziness; nervousness; paresthesia; somnolence; anxiety; headache; insomnia; weakness; drowsiness. Dermatologic Pruritus; rash; sweating. EENT Blurred or abnormal vision; conjunctivitis; tinnitus; nasal congestion; sinusitis; epistaxis; pharyngitis. GI Nausea; vomiting; dry mouth; diarrhea; constipation; abdominal discomfort or pain; flatulence. Genitourinary Impotence; urinary frequency; UTI. Respiratory Dyspnea; bronchitis; bronchospasm; flu symptoms; increased cough. Miscellaneous Shoulder, neck, back, or extremity pain; arthralgia; edema; fever; weight gain.

Interactions:

None well documented

Warnings:

Pregnancy Category C . Lactation Undetermined. Children Safety and efficacy not established. BPH complications Long-term effects on incidence of surgery, acute urinary obstruction, or other complications of BPH have not been determined. First-dose effect May cause marked hypotension (especially orthostatic) and syncope at 15 to 90 min after first few doses, after reintroduction, with rapid increase in dosing, or after addition of another antihypertensive; to avoid, initiate dosing with low dose and gradually increase after 2 wk; monitor patients carefully. Hemodilution Small decreases in hematocrit, hemoglobin, WBCs, total protein, and albumin may occur, possibly because of hemodilution.

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SOLUTION FOR INJECTION

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Consultants Corner

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

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