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Afebryl

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Indications:

Symptomatic treatment of pain and fever.

Contraindications:

History of hypersensitivity to salicylates, NSAIDs or tartrazine. Gastric ulcer or duodenal evolutionary gastrointestinal bleeding. Hemorrhagic diathesis and clinical situations where there is a risk of bleeding. Severe renal impairment. Risk of methemoglobinemia and hemolytic anemia especially in patients with a genetic deficiency of glucose-6-phosphate dehydrogenase. Liver failure and severe hypersensitivity to paracetamol or phenacetin. Patients undergo a strict regime désodé (for patients on a low salt diet, take account of the sodium: 14 mEq or tablet).

Adverse reactions:

Effects due to the presence of acetylsalicylic acid. Accidents awareness with respiratory or skin reactions (angioedema, urticaria, asthma, anaphylactic shock); Cross hypersensitivity reactions with NSAIDs and with tartrazine; At low doses recommended for the use of Afebryl, side effects of aspirin are generally limited to some irritation of the gastro-intestinal tract. At higher doses, side effects include gastrointestinal mucosal erosions, gastric ulcer or duodenal ulcer, occult blood loss, melena. Acetylsalicylic acid may also increase the tendency to bleeding and bleeding time (the lengthening of bleeding continues 4-6 days after stopping the drug). It may also worsen renal function including cases of pre-existing condition (the long-term use can cause chronic kidney disease). The signs of salicylic overdose described under. Effects due to the presence of paracetamol. At the doses and duration of recommended treatment, side effects are usually negligible, but the prolonged use of paracetamol in therapeutic doses large (2-4 g per day, or 10-20 tablets Afebryl) may cause the appearance chronic hepatitis.This justifies the recommendations of caution especially in patients with liver disease prior. Very rarely, it can produce thrombocytopenia. The acute liver toxicity in overdose massive (doses greater than 8 g of paracetamol) is described in paragraph overdose.

Interactions:

Potentiation of the action of coumadin and heparin mainly because of the anti-platelet acetylsalicylic acid. There is also an increased risk of bleeding from the gastrointestinal tract in case of injury. Potentiation of action of sulphonylureas. In general, it should not involve the Afebryl with other NSAIDs in particular because of the risk of aggravation of side effects. Increase due to acetylsalicylic acid activity and toxicity of methotrexate by displacing it from its binding site and protein by decreasing its renal tubular secretion. The gastric toxicity of acetylsalicylic acid is increased by alcohol. Acetylsalicylic acid, taken at the indicated doses, decreases the effects of all drugs uricosuric uricosuric. The use of enzyme-inducing drugs such as barbiturates may increase liver toxicity of paracetamol.

Warnings:

In children under 12 years, with suspected viral fever, it does not administer aspirin if other medicines do not provide sufficient results. Si une perte de connaissance et des vomissements persistants surviennent au cours d’un traitement par acide acétylsalicylique, il pourrait s’agir de signes du syndrome de Reye, une maladie très rare mais parfois à issue fatale, nécessitant un traitement médical. If loss of consciousness and persistent vomiting occur during treatment with acetylsalicylic acid, it could be signs of Reye’s syndrome, a very rare but sometimes fatal, requiring medical treatment. A causal relationship with the taking of drugs containing acetylsalicylic acid has not so far been established with certainty. Particular care will be taken in cases of asthma, a history of peptic ulcer or gastrointestinal bleeding, and in the event of menorrhagia, bleeding disorders and during concomitant oral anticoagulants. In the presence of mild to moderate renal insufficiency, the number of daily doses will be reduced as much as possible by increasing the time interval between each. The elderly need the same precautions. The dosage will be reduced during onset of side effects announcing salicylate poisoning including tinnitus or increase the frequency and respiratory amplitude. Often stopping the therapy will be necessary, it may eventually be resumed later at a lower dose. Recent studies have shown a possible correlation between the occurrence of Reye’s syndrome and the administration of salicylates in the presence of chickenpox or influenza B. The syndrome starts with respiratory symptoms and nonspecific gastrointestinal (repeated vomiting) and rapidly moving toward a brain deterioration with seizures, mental confusion and coma. The composition containing paracetamol, precautions must be taken in cases of mild or moderate hepatic insufficiency and chronic alcoholism. The content mEq sodium per tablet is 14: it must be taken into account in the establishment of a low salt diet. This medication contains aspirin. Do not use without medical advice in febrile children. This medicine contains paracetamol. Do not exceed the prescribed or recommended doses or prolonged treatment. Si les symptômes persistent, consultez votre médecin traitant. If symptoms persist, consult your doctor. Pregnancy and Lactation: Although no teratogenic effect has been demonstrated in women, aspirin is not recommended at least during the first three months of pregnancy.It must be avoided at the end of it because it may delay the date of delivery and prolonged labor. Furthermore, in women in late pregnancy, aspirin may be responsible for hemorrhagic stroke affecting both the mother and the fetus and the newborn and cause premature closure of the ductus arteriosus in utero.

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