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This medicine is used to treat a wide variety of bacterial infections, particularly infections caused by betalactamase-producing strains of the following: 1-Skin and skin structure infections caused by Staphylococcus aureus, Escherichia coli, Klebsiella species (including K. pneumoniae) , proteus mirabilis, Bacteroides fragilis, and Enterobacter species. 2-Intra-abdominal infections caused by E. coli, Klebsiella species (including K. pneumoniae), Bacteroides (including B. fragilis and Enterobacter) . 3-Gynecologic infections caused by E. coli and Bacteroides ( including B. fragilis).


This medicine is contraindicated in patients with known hypersensitivity to ampicillin or any penicillin medicine.

Adverse reactions:

This medicine may cause diarrhea, stomach upset, gas or nausea. Other side effects include itching, chest pain, skin rash, swelling of the face, hands or feet, difficulty breathing, difficult or painful urination, dizziness, unusual bleeding or bruising, sore throat or a swollen tongue. The site where the injection is given may be red and irritated for a few days. Use of This medicine for prolonged or repeated periods may result in a secondary infection (e.g., oral , bladder or vaginal yeast infection).


Antacids may reduce the absorption of ampicillin and decrease its effects. Tetracycline or erythromycin should not be taken in conjunction with ampicillin. These drugs may decrease the effect of ampicllin. Use of ampicillin with probenecid may increase blood levels of ampicillin and could cause toxicity. Ampicillin taken in conjunction with methotrexate may increase blood levels of methotrexate and could cause toxicity.This drug may decrease the effect of oral contraceptives. An alternate method of birth control should be used.


Patients with a history of allergics may be more likely to have a severe allergic reaction to a penicillin and beta-lactamase inhibitor combination. Besides, patients with mononucleosis may have an increased chance of skin rash when receiving ampicilin and sulbactam combination. This medicine should be used with caution in people with kidney impairment. If superinfections occur (usually involving pseudomonase or Candida) , the drug should be discontinued and appropriate therapy instituted. This medicine should be used only if clearly needed during pregnancy, since small amounts of this medication are found in breast milk , therefore, caution should be exercised when This medicine is administered to a nursing woman.



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