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Amsidine

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Indications:

Amsacrine belongs to the general group of medicines known as antineoplastics. It is used to treat acute adult leukemia. Amsacrine interferes with the growth of cancer cells, which are then eventually destroyed by the body. Since the growth of normal body cells may also be affected by amsacrine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur until months or years after the medicine is used.

Contraindications:

Pregnancy. Lactation. Hypersensitivity.

Adverse reactions:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Accumulation of pus or swollen, red, tender area of infection around the rectum Black tarry stools blood in urine or stools cough or hoarseness fever or chills lower back or side pain painful or difficult urination pinpoint red spots on skin sores, ulcers, or white spots on lips, tongue, or inside mouth unusual bleeding or bruising unusual tiredness or weakness Less common Abdominal pain or tenderness blurred vision confusion dark urine diarrhea dizziness, faintness, or light-headedness fast, pounding, or irregular heartbeat or pulse fever itching nausea palpitations convulsions (seizures) vomiting or vomiting of blood or material that looks like coffee grounds yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Burning, crawling, numbness, prickling, “pins and needles”, or tingling feelings headache Less common Bleeding gums difficulty swallowing hives loss of appetite loss of strength or energy muscle or bone pain pain or redness at site of injection rash redness and swelling of gums amsacrine often causes a temporary loss of hair. After treatment with amsacrine has ended, normal hair growth should return. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Interactions:

Using amsacrine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Rotavirus Vaccine, Live Using amsacrine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Bacillus of Calmette and Guerin Vaccine, Live Influenza Virus Vaccine, Live Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Poliovirus Vaccine, Live Rotavirus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Vaccine St John’s Wort Typhoid Vaccine Varicella Virus Vaccine Yellow Fever Vaccine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Warnings:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amsacrine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to amsacrine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Studies on amsacrine have been done only in adult patients, and there is no specific information comparing use of amsacrine in children with use in other age groups. Geriatric Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of amsacrine in the elderly with use in other age groups. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. It is very important that your doctor check your progress at regular visits to make sure that amsacrine is working properly and to check for unwanted effects. While you are being treated with amsacrine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor’s approval. Amsacrine may lower your body’s resistance, and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine, since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the last several months. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth. Amsacrine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding: If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur. If amsacrine accidentally leaks out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the doctor or nurse right away if you notice redness, pain, or swelling at the place of injection.

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SOLUTION FOR INJECTION

Dosage and Administration

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