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Indications:

Parenteral:Diagnosis of hypothalamic-pituitary-gonadal dysfunction, Parenteral: Primary hypothalamic amenorrhoea

Contraindications:

Pituitary adenoma; weight-related amenorrhoea; pregnancy.

Adverse reactions:

GI disturbances; headache, lightheadedness, increase in menstrual bleeding; paradoxical suppression of the pituitary gonadal axis; hot flushes and sexual dysfunction in men; vaginal dryness, hot flushes, loss of libido in premenopausal women; osteoporosis if sufficiently prolonged; ovarian hyperstimulation; Inj site reactions/pain; tumor flare (may manifest as increase in bone pain); effects related to changes in the hormonal milieu.

Interactions:

Spironolactone and levodopa can stimulate gonadotrophins while phenothiazines and dopamine antagonists can inhibit gonadotrophin secretion. Corticosteroids and drugs affecting pituitary secretion of gonadotrophins may also affect efficacy of the drug.

Warnings:

Women with polycystic ovary disease or endometriotic cysts. May also increase cervical resistance thus making it difficult to dilate the cervix for intra-uterine procedures. Monitor men at risk of tumor flare. Pituitary adenoma. Pregnancy category B.

Form:

SOLUTION FOR INJECTION

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