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This medication is used to treat various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. It decreases your body’s natural defensive response and reduces symptoms such as swelling and allergic-type reactions. Hydrocortisone is a corticosteroid hormone (glucocorticoid). This injectable form of hydrocortisone is used when a similar drug cannot be taken by mouth or when a very fast treatment is needed, especially in patients with severe medical conditions. This drug may also be used with other medications as a replacement for certain hormones.


Prior Arthroplasty of joint , Blood Clotting disorders , intra – articular fracture , infection ( periaticular , current or history of ) , osteoporosis , unstable joint.

Adverse reactions:

Stomach upset, headache, dizziness, menstrual period changes, trouble sleeping, increased appetite, weight gain, or pain/redness/swelling at the injection site may occur.


aldesleukin, large doses of aspirin and aspirin-like drugs (salicylates such as salsalate), birth control pills/patch/ring, "blood thinners" (e.g., warfarin), bupropion, drugs for diabetes, drugs that cause potassium loss (e.g., amphotericin B, diuretics such as hydrochlorothiazide, furosemide), estrogens, mifepristone, natalizumab, nonsteroidal anti-inflammatory drugs (NSAIDs such as indomethacin, ibuprofen), quinolone antibiotics (e.g., levofloxacin), drugs affecting liver enzymes that remove hydrocortisone from the body (e.g., aprepitant, azole antifungals such as ketoconazole, macrolide antibiotics such as erythromycin, rifamycins such as rifampin, certain anti-seizure medications such as phenytoin and phenobarbital), herbal products (e.g., licorice).


Sodium bisulfite may cause allergic – type reactions including an anaphylactic symptoms .Systemic corticosteroids should be used with great caution in the presence of heart failure , recent MI , hypertension , diabetes mellitus , epilepsy , glaucoma , hypothyroidism , hepatic failure , osteoporosis , peptic ulceration , psychoses or severe affective disorders , and renal impairment , growth retardation in children , live vaccines should not be give to patients receiving high-dose systemic corticosteroid therapy nor for atleast 3 months afterwards . killed vaccines or toxoids may be given although the response may be attenuated . During prolonged courses , sodium intake may need to reduced and calcium and potassium supplements may be necessary . Rapid intravenous injection of massive doses of corticosteroids may sometimes cause cardiovascular colapse and injections should therefore be given slowly or by infusion .



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