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Camptosar

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Info

Indications:

Refractory colorectal malignancies Hepatic impairment

Contraindications:

Inflammatory bowel disease, bowel obstruction, severe hepatic impairment. Pregnancy and lactation.

Adverse reactions:

Neutropenia, anaemia, thrombocytopenia; acute diarrhoea, sweating, hypersalivation, abdominal cramps, lachrymation, miosis, weakness; nausea, vomiting, alopecia and skin reactions; cardiovascular toxicity. Potentially Fatal: Fatal sepsis due to myelosuppression; severe, chronic diarrhoe

Interactions:

Diuretics increase risks of dehydration secondary to vomiting/diarrhoea; prophylactic dexamethasone as an antiemetic may enhance lymphocytopenia; prochlorperazine may increase incidence of akathisia; antineoplastic agents (myelosuppression and diarrhoea)

Warnings:

Previous pelvic/abdominal irradiation; elderly; Raised plasma-bilirubin concentration; severe myelosuppression. Avoid extravasation.

Form:

INJECTION

Dosage and Administration

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