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D-cycloserin

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Indications:

used with other medication in the treatment of tuberculosis infections. It is also used to treat certain types of urinary tract infections.

Contraindications:

Severe renal impairment, porphyria, depression, epilepsy, severe anxiety, psychosis, chronic alcoholism, hypersensitivity.

Adverse reactions:

Headache, dizziness, anxiety, confusion, irritability, paraesthesia, speech difficulties, photosensitivity, vertigo, drowsiness, tremor, psychosis, depression; rashes; megaloblastic anaemia; changes in liver function tests. Potentially Fatal: Convulsions (dose related).

Interactions:

Concurrent usage with other antituberculosis drugs may lead to vitamin B12 and/or folic acid deficiency, megaloblastic and sideroblastic anemia. Potentially Fatal: Inhibits phenytoin metabolism and may increase risk of epileptic seizures. Alcohol increases risk of convulsions. Increased CNS toxicity with isoniazid and ethionamide.

Warnings:

Discontinue or reduce dose if allergic skin reactions or CNS toxicity occurs; monitor haematological, renal and hepatic function; Blood levels should be determined wkly for renally impaired patients or if dose exceeds 500 mg/day or if there are signs of neurological toxicity. Pregnancy and lactation. pregnancy: Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

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