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Cyprone

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Indications:

hormonal therapy that is used in the treatment of prostate cancer. -Deviant sexual behaviour

Contraindications:

Pregnancy, lactation, liver diseases, history of jaundice or persistent itching during previous pregnancy or a history of herpes of pregnancy; Dubin-Johnson syndrome, Rotor syndrome, previous or existing liver tumours (in carcinoma of the prostate only if they are not due to metastases); wasting diseases (exception: prostatic carcinoma); severe chronic depression; previous or existing thromboembolic processes, severe diabetes w/ vascular changes, sickle cell anaemia.

Adverse reactions:

Very common (affect more than 1 in 10 people) * Decreased sperm count (reversible on stopping treatment). * Reduced volume of ejaculation (reversible on stopping treatment). Common (affect between 1 in 10 and 1 in 100 people) * Weight changes. * Depressive moods. * Restlessness. * Enlargement and tenderness of breasts (gynaecomastia). * Fatigue. Uncommon (affect between 1 in 100 people and 1 in 1000 people) * Rash. Rare (affect between 1 in 1000 and 1 in 10,000 people) * Shortness of breath. * Liver disorders. * Dryness of skin. * Abnormal blood clots in the blood vessels (thromboembolism). * Reduced growth of body hair and increased growth of scalp hair. * Abnormal production of breast milk (galactorrhoea). * Lightening of hair colour. * Severe allergic reaction. Very rare (affect less than 1 in 10,000 people) * Osteoporosis. * Liver cancer.

Interactions:

Metabolism may be reduced by inhibitors of CYP3A4 e.g. ketoconazole, itraconazole, clotrimazole, ritonavir. Inducers of CYP3A4 e.g. rifampicin, phenytoin may reduce the levels of cyproterone. Food Interaction Efficacy may be reduced by alcohol. St John’s wort may reduce the levels of cyproterone.

Warnings:

Diabetes. Prostatic carcinoma: Careful risk-benefit evaluation in the case of sickle cell anaemia, severe diabetes w/ vascular changes or if there is a history of thromboembolic processes. In extremely rare cases, the occurrence of thromboembolic events has been reported. Benign & malignant liver changes have been reported in isolated cases. In very rare cases, liver tumours may lead to life-threatening intra-abdominal haemorrhage. If severe upper abdominal complaints, liver enlargement or signs of intra-abdominal haemorrhage occur, a liver tumour should be taken into consideration. Regular exam of liver function, adrenocortical function & RBC count. Should not be given before the conclusion of puberty. In women: If persistent or recurrent bleeding occurs during therapy, treatment must be interrupted until organic diseases have been excluded.

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