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Indications:

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Hydrocodone is in a group of drugs called narcotics and is similar to codeine. Hydrocodone is a cough suppressant that affects the signals in the brain that trigger cough reflex. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). The combination of chlorpheniramine, hydrocodone, and pseudoephedrine is used to treat cough, sneezing, itching, watery eyes, runny nose, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Contraindications:

Do not use this medication if you are allergic to hydrocodone or other narcotic pain relievers such as fentanyl (Actiq, Duragesic), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (Oxycontin), and oxymorphone (Opana). Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Before taking chlorpheniramine, hydrocodone, and pseudoephedrine, tell your doctor if you are allergic to any drugs, or if you have: kidney or liver disease; heart disease or high blood pressure; enlarged prostate or urination problems; diabetes; glaucoma; a thyroid disorder; asthma, COPD, sleep apnea, or other breathing disorders; a history of head injury or brain tumor; epilepsy or other seizure disorder; low blood pressure; gallbladder disease; Addison’s disease or other adrenal gland disorders; mental illness; or a history of drug or alcohol addiction.

Adverse reactions:

fast, pounding, or uneven heartbeats; shallow breathing, slow heartbeat; severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor; confusion, hallucinations, unusual thoughts or behavior; easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; urinating less than usual or not at all; or increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure). Less serious side effects may include: blurred vision; dry mouth; nausea, vomiting, stomach pain, constipation, mild loss of appetite; mild dizziness, drowsiness; problems with memory or concentration; ringing in your ears; warmth, tingling, or redness under your skin; restless or excitability (especially in children); sleep problems (insomnia); or skin rash or itching.

Interactions:

Before taking this medication, tell your doctor if you are using any of the following drugs: cimetidine (Tagamet); rifampin (Rifadin, Rifater, Rifamate, Rimactane); zidovudine (Retrovir, AZT); antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others; aspirin or salicylates (such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others); a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others; bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); a diuretic (water pill), or blood pressure medication; medication to treat irritable bowel syndrome; medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril); or seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton)

Warnings:

Do not drink alcohol while you are taking this medication. Alcohol can increase some of the side effects of chlorpheniramine, hydrocodone, and pseudoephedrine. Do not take this medication with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Life-threatening side effects may result. Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. Chlorpheniramine and pseudoephedrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains chlorpheniramine or pseudoephedrine.

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Dosage and Administration

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Consultants Corner

Dr. Samer Al-Jneidy

Dr. Samer Al-Jneidy Pediatrician

Yaser Habrawi , F.R.C.S.Ed

Yaser Habrawi , F.R.C.S.Ed Consultant Ophthalmologist

Dr. Talal Sabouni

Dr. Talal Sabouni UROLOGY AND KIDNEY TRANSPLANT

Dr . Dirar Abboud

Dr . Dirar Abboud Hepatologist – Gastroenterologist

Dr. Hani Najjar

Dr. Hani Najjar Pediatrics, Neurology

Samir Moussa M.D.

Samir Moussa M.D. ENT Specialist

Dr. Faisal Dibsi

Dr. Faisal Dibsi Specialist of Otolaryngology - Head and Neck Surgery

Dr. Tahsin Martini

Dr. Tahsin Martini Degree status: M.D. in Ophthalmology
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