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New Anesthetics Better Options For Elders

New Anesthetics Better Options For Elders

(ePharmaNews) - “Counting down from ten, nine, eight, seven, "and before the patient reaches the five, he goes into a deep sleep, waking up few hours later without a clue of what happened during the operation. Anyway, doctors recently have expressed concerns that some drugs used in anesthesia extend the “forgetting effect" to a prolonged period, especially if the patient is old and suffering from memory problems.

To find out which anesthesia drugs are safer for amnesic old patients, like Alzheimer's patients, researchers compared the effect of a common medication, the inhalant anesthetic “isoflurane”, with a new drug called “desflurane”.
The study was done in order to determine their impact on memory and learning ability. Both drugs belong to the inhaled anesthetics, which are passed with oxygen through a special mask on the patient's nose and mouth during the operation.
The researchers found in this study, published in the Annals of Neurology, that isoflurane leads to increased oxidative substances and accumulation within the nerve cell which increases cell's injury and may lead to its death. Notably, this is the same effect of Alzheimer on the brain leading to the deterioration of memory and mental abilities. Scientist did not find such effect in animal models which inhaled Desflurane.

 The researchers followed the study by saying: “These findings suggest that desflurane could be a safer anesthetic for AD patients as compared to isoflurane, and elucidate the potential mitochondria-associated underlying mechanisms, and therefore have implications for use of anesthetics in AD patients, pending human study confirmation. “

Dr. Huda Al-Nasser, head of anesthesia and resuscitation department in Aleppo University Hospital, said to ePharmaNews: “ This study is completely biological, which suggests that desflurane  is safer to Alzheimer's patients than isoflurane,  but we need further studies to confirm this result, especially that it is known that isoflurane has a protective effect on cells called  (Reconditioning) , which means that it protects against neurons injury in cases of ischemia and lack of oxygen during operations“
About the use of desflurane in the Middle East, she said: “ This is a relatively expensive drug and requires special evaporators, but recently it started to be used in Jordan, while isoflurane and halothane are considered  the most widely used inhalation drugs in Syria“.

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Edited By: Laila Nour

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