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Long-term Hormones Use Increases Breast Cancer Risk

Long-term Hormones Use Increases Breast Cancer Risk

(ePharmaNews) - Perhaps a lot of women consider the twenty-eight pill of OCP a magical solution for the menopause symptoms, but it seems that they have to reconsider the idea, as a new U.S. study questioned the safety of these pills claiming that it may cause an increased risk of breast cancer when used for more than ten years.

Women adopted hormones for decades - and still - in order to alleviate the menopause symptoms of, hot flashes and sweating, resulting from the disruption of women ovarian function of producing feminine hormones; estrogen and progesterone. The hormone therapy compensates the shortage of the levels of these hormones, restoring the stability of the woman's body. Anyway,  scientists has always warned of an increased risk of several serious diseases, caused by Hormone replacement therapy, such as osteoporosis, strokes, heart disease and even some types of cancer.

Researchers evaluated follow-up data from the Nurse's Health Study collected from 1980 through 2008. The women in the study were 30 to 55 years old in 1976. Overall, the risk for breast cancer was 88% higher among women who had taken estrogen plus progesterone for 10 to 15years, compared to women who did not. This risk more than doubled for women who used estrogen-plus-progesterone therapy for 15 to 20 years.

Women who used estrogen-only therapy after menopause had 22 percent increased risk for breast cancer if they used it for 10 to 15 years and 43 percent greater risk if they used it longer than 15 years. There was no increased risk seen among women who took estrogen for fewer than 10 years. Women did not have an increased risk of dying from breast cancer, the study showed.

"For combination therapy there is so much data about the dangers that we really tell people that if they must take it to treat symptoms, they should only do so for a year or two at most," said study author Dr. Wendy Chen, an associate physician at Brigham and Women's Hospital and an assistant professor in medicine at the Breast Cancer Treatment Center at the Dana-Farber Cancer Institute in Boston. "For estrogen alone, there is more safety data for someone who wants to take it for five or six years."

It is noteworthy that the study was presented at the annual meeting of the American Association for Cancer Research in Chicago on April, the first. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal, so doctors are advised that women should take the minimum dose and for the least possible period of time.

اضغط هنا للقراءة باللغة العربية

Prepared by: Mohammed Kanjo
Translated by: Marcell Shehwaro

Source :


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