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Viagra; Cure for Diabetes Problems


Viagra; Cure for Diabetes Problems

(ePharmaNews) – Sildenafil can help diabetic patients with erectile dysfunction, but recent laboratory study showed that the effect of Sildenafil might be broader, as it indicated that these blue pills may help treating heart and vascular diseases and modify the cellular response to insulin as well.

Type-II diabetes, which occurs due to resistance of insulin, causes reduced effectiveness of a group of enzymes that are necessary for the correct function of the heart and the vessels. Such defects may lie behind the mechanism of vasodilatation that eventually disturbs the blood supply for vital organs.

The researchers began their studies depending on their knowledge of the role of sildenafil (the active ingredient in Viagra) in increasing the effectiveness of such enzyme. They conducted a laboratory experiment to test whether Viagra® can help restoring the normal vascular function and decreasing the insulin resistance.
During the study, which was done in Rome, the researchers used samples from the lining cells of umbilical vein, the samples were enriched with insulin, some sugars and finally sildenafil. They monitored the changes that happened in the sample, which represents a micro environment of humans' blood vessels.

The results showed, as published today in PLoS one journal, that sildenafil treatment had contributed significantly to restoring the cells natural response to insulin, and increasing their metabolic activity.
”These data indicate that sildenafil might improve [the enzyme's] activity of endothelial cells in insulin resistance conditions and suggest the potential therapeutic use of sildenafil for improving vascular function in diabetic patients.” Dr. Caterina Mammi, the lead researcher, said.
 
Finally, targeting one of the enzymes responsible for diabetes' complications, is considered a naïve approach in the meanwhile, as most of current treatments of diabetes depend on controlling blood sugar to prevent cellular injuries, rather than fixing the defects after their onset. 


اضغط هنا للقراءة باللغة العربية

Prepared by: Houssam Nahhas
Translated by: Marcell Shehwaro


Source :

ePharmaNews






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