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Changing Medications Route Changes Effectiveness


Changing Medications Route Changes Effectiveness

(ePharmaNews) - A new study has found that changing the way Parkinson's patients are given their commonly used medication may reduce one of the most important problems that face them years after their diagnosis.

This study was presented yesterday as part of the Emerging Science program (formerly known as Late-Breaking Science) at the American Academy of Neurology’s 64th Annual Meeting in New Orleans April 21 to April 28, 2012, and showed that giving levodopa-carbidopa (The cornerstone treatment in Parkinson)
through a portable pump connected to a tube implanted in the intestine -similar to a feeding tube- works better than standard oral admission in reducing “off” time in patients with advanced Parkinson’s disease.
“Off” time occurs when Parkinson’s symptoms like tremor, slowness, stiffness and walking difficulty return as the beneficial effects of oral treatments wear off.
‘“Off’ time was reduced because the infusion of LCIG helps to deliver levodopa-carbidopa continuously, thereby avoiding the fluctuating levels that occur with standard oral levodopa-carbidopa therapy and that are thought to contribute to the development of wearing off,” said study author C. Warren Olanow, MD, Professor of Neurology and Neuroscience at the Mount Sinai School of Medicine in New York and a Fellow of the American Academy of Neurology.
In the three-month double-blind trial, 71 participants were randomized to receive either the continuous infusion of LCIG and dummy pills or a dummy intestinal gel and pills that contained levodopa and carbidopa. At the start of the study, the average person had Parkinson’s disease for about 11 years and experienced 6.6 hours of “off” time per day. A total of 93 percent of participants completed the study.


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Prepared by: Laila Nour


Source :

ePharmaNews






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